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شیمی::
حلالیت آبی
Although simple conventional formula- tion technologies are preferred at this stage, such technologies are often not applicable for challenging compounds, such as those exhibiting poor aqueous solubility (Chaubal, 2004).
• Poor aqueous solubility
• Low aqueous solubility
Phosphate ester prodrugs are typically designed for hydroxyl and amine functionalities of poorly water-soluble drugs with the aim of enhancing their aqueous solubility to allow more favorable oral or parenteral administration.
This design of pro- drug enhances the aqueous solubility to allow more favorable oral or parenteral administration.
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